Ciliary neurotrophic factor: Pharmacokinetics and acute-phase response in rat
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چکیده
منابع مشابه
Ciliary neurotrophic factor: pharmacokinetics and acute-phase response in rat.
Ciliary neurotrophic factor (CNTF) supports the survival of motoneurons in vitro and in vivo. Recombinant CNTF is an investigational drug for the treatment of amyotrophic lateral sclerosis. We determined the pharmacokinetics of radioiodinated CNTF after intravenous injection into rats. CNTF shows a biphasic clearance with an initial plasma half-life of 2.9 minutes and is removed from the circul...
متن کاملThe trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat
Objective(s): Occlusal trauma is one of the most common forms of oral biting dysfunction. Long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. Through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (CNTF) on injured masseter muscle. Materials and Methods: Male Wistar rats (n=36) were random...
متن کاملthe trophic effect of ciliary neurotrophic factor on injured masseter muscle in rat
objective(s): occlusal trauma is one of the most common forms of oral biting dysfunction. long-term occlusal trauma could weaken the stomatognathic system; especially damage one’s masticatory muscle. through using the rat model, this study investigated the trophic effect of ciliary neurotrophic factor (cntf) on injured masseter muscle. materials and methods: male wistar rats (n=36) were randoml...
متن کاملgp130 signaling in proopiomelanocortin neurons mediates the acute anorectic response to centrally applied ciliary neurotrophic factor.
Ciliary neurotrophic factor (CNTF) exerts anorectic effects by overcoming leptin resistance via activation of hypothalamic neurons. However, the exact site of CNTF action in the hypothalamus has not yet been identified. Using Cre-loxP-mediated recombination in vivo, we have selectively ablated the common cytokine signaling chain gp130, which is required for functional CNTF signaling, in proopio...
متن کاملLeukemia inhibitory factor and ciliary neurotrophic factor cause dendritic retraction in cultured rat sympathetic neurons.
Dendritic retraction occurs in many regions of the developing brain and also after neural injury. However, the molecules that regulate this important regressive process remain largely unknown. Our data indicate that leukemia inhibitory factor (LIF) and ciliary neurotrophic factor (CNTF) cause sympathetic neurons to retract their dendrites in vitro, ultimately leading to an approximately 80% red...
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ژورنال
عنوان ژورنال: Annals of Neurology
سال: 1994
ISSN: 0364-5134,1531-8249
DOI: 10.1002/ana.410350206